Megaloblastic Anaemia Occurring During Primidone Therapy
نویسندگان
چکیده
منابع مشابه
Lymphadenopathy and megaloblastic anaemia in patient receiving primidone.
Medical Memoranda BRmrns 215 the same day her haemoglobin dropped to 5.4 g. with 5% reticulo-cytes. A second blood transfusion was given, steroids were continued, and chloramphenicol was started. Her temperature dropped within three days and she remained afebrile. The haemoglobin was 8.5 g. on the twenty-seventh day of the illness and 10.5 g. a month later. COMMENT All five cases were anaemic o...
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In 1954 Badenoch described two cases of megaloblastic anaemia which developed in epileptics while under treatment with phenytoin sodium and phenobarbitone, and subsequently I2 further cases have been recorded (Hawkins and Meynell, 1954; Chalmers and Boheimer, I954; Rhind and Varadi, I954; Webster, 1954; Berlyne, Levene and McGlashan, 1955; Ryan and Forshaw, I955; Vaishnava, I955). Six of these ...
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HILE the umsderhyimmg causes of the nsajority of misegaloblast-ic amsemssias are usow knsown, the list is usotyet exhaustive amid it has recemstly been suggested that amsticomsvulsammt drutgs nsay commstitute a mies ’ etiohogic fact-or its sonic cases. The postulated effectof these drutgs is particutlarly strikimsg ins that megaloblastic ausemia is msot seems wit-h the niomispecific toxic agcmm...
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Urinary amino-acid chromatograms from 23 patients with megaloblastic anaemia have been studied before and after therapy. The most consistent abnormality was an increased taurine or increased taurine/glycine ratio. This was not related directly to deficiency of vitamin B(12) or folic acid or to the degree of anaemia.
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IN 1877 Muller described a marked bronzed discoloration of the skin in some patients considered to have pernicious anaemia. This observation, confirmed later by Immerman (1879) is likely to be the first record of an association between a macrocytic type of anemia and haemochromatosis. Since that time French (1909), Roth (1915), Bork (1928), Cain (1940), Hotz (1944) and Harvier and Mallarme (193...
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ژورنال
عنوان ژورنال: BMJ
سال: 1956
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.4959.146